METHOD FOR PRODUCING SPIROOXINDOLE DERIVATIVE

摘要

Provided is a method with which it is possible to efficiently manufacture a compound having a spirooxindole structure, for example a compound having a spirooxindole structure and having antitumor activity which inhibits the interaction between Mdm2 protein and p53 protein, or an intermediate of of said compound, using an asymmetric catalyst. By performing a catalytic asymmetric 1,3-bipolar cyclic addition using a chiral ligand and Lewis acid, with ketimine as a reaction substrate, a compound having an optically active tricyclic dispiroindole structure is obtained efficiently.