NOVEL SYNTHETIC ANALOGS OF SPHINGOLIPIDS

摘要

The present invention provides new ceramide analogs indicated as the compounds of formula (II). These novel analogs exhibit a significant anti cancerous effect and are therefore provided as a pharmaceutical composition for treating cell proliferative diseases, neurodegenerative disorders, metabolism-associated conditions, infectious diseases, and immune-related disorders. The invention further provides combined compositions and kits combining the novel ceramide analogs of formula (II) with an additional therapeutic agent.

主权项

1. A compound of formula (II) wherein X represents OH; Y representswherein R6 represents a C2-20 linear or branched alkyl or alkenyl chain which may be optionally substituted with hydroxyl; and
W represents C1-20 linear or branched alkyl or alkenyl chain substituted with hydroxyl, or a pharmaceutically acceptable salt or isomer thereof.