发明名称 |
1,2,4-OXADIAZOLE DERIVATIVES AS IMMUNOMODULATORS |
摘要 |
The present invention relates to 1,2,4-oxadiazole and 1,2,4-thiadiazole compounds as therapeutic agents capable of inhibiting the programmed cell death 1 (PD1) signaling pathway. The invention also refers to derivatives of the therapeutic agents. The invention also encompasses the use of the said therapeutic agents and 5 derivatives for treatment of disorders via immunopotentiation comprising inhibition of immunosuppressive signal induced due to PD-1, PD-L1, or PD-L2 and therapies using them. |
申请公布号 |
CA2922607(A1) |
申请公布日期 |
2015.03.12 |
申请号 |
CA20142922607 |
申请日期 |
2014.09.05 |
申请人 |
AURIGENE DISCOVERY TECHNOLOGIES LIMITED |
发明人 |
SASIKUMAR, POTTAYIL GOVINDAN NAIR;RAMACHANDRA, MURALIDHARA;NAREMADDEPALLI, SEETHARAMAIAH SETTY SUDARSHAN |
分类号 |
C07D271/06;A61K31/4245;A61K31/433;C07D285/08 |
主分类号 |
C07D271/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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