SUSTAINED RELEASE FORMULATION COMPRISING OCTREOTIDE AND TWO OR MORE POLYLACTIDE-CO-GLYCOLIDE POLYMERS

摘要

PROBLEM TO BE SOLVED: To provide novel sustained release formulations for long-term maintenance therapy in acromegalic patients and for treatment of severe diarrhea and flushing associated with malignant carcinoid tumors and vasoactive intestinal peptide tumors (vipoma tumors).SOLUTION: The present invention relates to sustained release formulations comprising as active ingredients octreotide or a pharmaceutically acceptable salt thereof and two or more different polylactide-co-glycolide polymers (PLGAs).