| 发明名称 |
CRYSTALLINE FORMS OF (N,N-DIETHYLCARBAMOYL)METHYL METHYL (2E)BUT-2-ENE-1,4-DIOATE, METHODS OF SYNTHESIS AND USE |
| 摘要 |
Disclosed herein are crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, which is a prodrug of methyl hydrogen fumarate. Crystalline form 1, Crystalline form 2, Crystalline 3, and Crystalline form 4 are disclosed. |
| 申请公布号 |
US2015073049(A1) |
申请公布日期 |
2015.03.12 |
| 申请号 |
US201414478627 |
申请日期 |
2014.09.05 |
| 申请人 |
XenoPort, Inc. |
发明人 |
Mao Chen;Scheuerman Randall A.;Karaborni Sami |
| 分类号 |
C07C235/06 |
主分类号 |
C07C235/06 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A crystalline form of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate selected from: Crystalline form 1 having a purity of at least 99% by weight as measured by HPLC; Crystalline form 2; Crystalline form 3; or Crystalline form 4. |
| 地址 |
Santa Clara CA US |
