MODULATION OF γδT CELLS

摘要

The present invention relate to the discovery that BTLA, IL-7 and RORγt modulate the activity and expression of γδ&Tgr; cells. Specifically, the present invention provides methods of modulating γδ&Tgr; cell homeostasis and function by regulating expression of BTLA. The present invention further provides agents which modulate the activity and expression of BTLA, RORyt and IL-7 and methods for screening of such agents. The present invention also provides methods for treating autoimmune or inflammatory diseases using modulators of BTLA, RORyt and IL-7.