PROCESS FOR PREPARING BIPHENYL IMIDAZOLE COMPOUNDS

摘要

PROBLEM TO BE SOLVED: To provide processes for preparing intermediates useful for preparing compounds of the formula (IV) or salts thereof.SOLUTION: The invention provides processes for preparing intermediates useful for preparing compounds of the formula (IV) or salts thereof, where Rare as defined in the specification. In one embodiment, this process further comprises the step of preparing a crystalline form of the compound of formula II. One aspect of the invention relates to crystalline 4'-(5-aminomethyl-2-ethoxy-4-ethylimidazol-1-ylmethyl)-3'-fluorobiphenyl-2-carboxylic acid t-butyl ester.