Oncolytic Adenoviruses for Cancer Treatment

摘要

The invention relates to an oncolytic adenovirus for the treatment of cancer, containing a human DNA sequence isolating a promoter conferring selective expression on an adenoviral gene. Said adenovirus can also contain a sequence that optimizes the protein translation of an adenoviral gene regulated by a promoter conferring tumor selectivity. The invention is suitable for use in the treatment of cancer.

主权项

1. An oncolytic adenovirus to treat cancer, the adenovirus comprising: an E1a gene, the E1a gene comprising a delta-24 mutation; a tumor selective promoter upstream of the E1a gene that confers tumor selective expression of the E1a gene; and a myotonic dystrophy insulator upstream of the promoter that comprises a sequence encoding a CTCF binding site and insulates the promoter against transcriptional interference.