发明名称 |
CANCER THERAPY VIA A COMBINATION OF EPIGENETIC MODULATION AND IMMUNE MODULATION |
摘要 |
Cancer therapies that combine epigenetic modulating agent(s) with immune modulating agent(s), which were remarkably identified to provide an improved treatment regimen over single agent therapy, are disclosed. In particular embodiments, the invention provides for improved treatment of NSCLC in patients via administration of exemplary immune modulating agents anti-PD-1 antibody or anti-PD-L1 antibody, which were observed to show enhanced activity in combination with the exemplary epigenetic modulating agent 5- deoxyazacytidine. Further, expression markers of responsive neoplastic cells are also disclosed. |
申请公布号 |
WO2015035112(A1) |
申请公布日期 |
2015.03.12 |
申请号 |
WO2014US54201 |
申请日期 |
2014.09.05 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
BAYLIN, STEPHEN B.;PARDOLL, DREW M.;TOPALIAN, SUZANNE L. |
分类号 |
A61K31/341;A61P35/00 |
主分类号 |
A61K31/341 |
代理机构 |
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代理人 |
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