摘要 |
Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and neurological disorders, including, but not limited to, e.g., psychosis, schizophrenia, depression, movement disorders, and Parkinson's disease. |
主权项 |
1. A compound of formula (I):or a pharmaceutically acceptable salt or stereoisomer thereof, wherein
n is 2, 3, or 4; W is O, NR5, or CH2; X is N or CH; Y is N or CH; each R10 and each R11 are independently H, F, OH, or (C1-C4)alkyl; (i) R1 is amido, sulfonamido, optionally substituted imidazolyl, or optionally substituted pyrazolyl; and R2 is H, halogen, CN, (C1-C4)alkyl, or (C1-C3)alkoxyl; or (ii) R1 and R2 together with the carbon atoms to which they are attached form a 5-, 6-, or 7-membered aryl, heteroaryl, cycloalkyl, or heterocyclyl ring, each of which is optionally substituted with one to three R6; R3 and R4 together with the nitrogen atom to which they are attached form an optionally substituted heterocyclyl Q; Q is R5 is H or (C1-C3)alkyl; each R6 is independently OH, keto, halogen, CN, (C1-C3)alkyl, or (C1-C3)alkoxyl; R7 is 5- to 10-membered aryl or heteroaryl, each optionally substituted with one to three substituents; and Ring Ar is a benzo, pyrazolo, pyrido, thieno, pyrimido, pyrazino, furano, pyridazino, thiazolo, or imidazolo ring, each optionally substituted with one to three substituents; provided that: (i) when Q isthenis notand
(ii) when Ar is an optionally substituted benzo ring, thenis not |