摘要 |
The present invention generally relates to libraries, compositions, methods, applications, kits and screens used in functional genomics that focus on gene function in a cell and that may use vector systems and other aspects related to Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas systems and components thereof. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. |
申请人 |
THE BROAD INSTITUTE INC.;MASSACHUSETTS INSTITUTE OF TECHNOLOGY;ZHANG, FENG;SHALEM, OPHIR;SANJANA, NEVILLE, ESPI;DOENCH, JOHN;ROOT, DAVID;BIEWENER HARTENIAN, ELLA NICOLE |
发明人 |
ZHANG, FENG;SHALEM, OPHIR;SANJANA, NEVILLE, ESPI;DOENCH, JOHN;ROOT, DAVID;BIEWENER HARTENIAN, ELLA NICOLE |