发明名称 |
POLYMERIC SYSTEMS FOR THE DELIVERY OF ANTICANCER DRUGS |
摘要 |
The present invention relates to compositions for the treatment of cancerous tissues in warm-blooded animals containing one or two anticancer agents attached to polymeric carriers having monomer units derived from one or more of N-(2-carboxypropyl)methacrylamide (2-CPMA), N-(3-carboxypropyl)methacrylamide (3-CPMA), N-(2-aminopropyl)methacrylamide (2-APMA) and/or N-(3-aminopropyl)methacrylamide (3-APMA) are also included. Anticancer agents in compositions can be attached to said polymeric carrier by side-chains which can be susceptible to hydrolysis by lysosomal enzymes intracellularly. Compositions can also include a targeting ligand attached to the polymeric carrier, optionally through a second linker. |
申请公布号 |
US2015071872(A1) |
申请公布日期 |
2015.03.12 |
申请号 |
US201414481593 |
申请日期 |
2014.09.09 |
申请人 |
REXAHN PHARMACEUTICALS, INC. |
发明人 |
Lee Young Bok;Kim Deog J.;Ahn Chang H. |
分类号 |
A61K47/48;A61K31/7068;A61K33/24;A61K31/337 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Rockville MD US |