发明名称 |
TREATMENT OF INFLAMMATORY DISEASES BY CARBON MATERIALS |
摘要 |
In some embodiments, the present disclosure pertains to methods of treating an inflammatory disease in a subject by administering a carbon material to the subject. In some embodiments, the carbon material selectively targets T cells in the subject. In some embodiments, the carbon material includes poly(ethylene glycol) -functionalized hydrophilic carbon clusters. In some embodiments, the administration of the carbon material to the subject reduces or inhibits T cell-mediated reactions in the subject. In some embodiments, the carbon material selectively targets T cells over other types of immune cells by preferential uptake into the T cells. In some embodiments, the carbon material reduces or inhibits proliferation of targeted T cells, reduces or inhibits cytokine production by targeted T cells, and reduces intracellular oxidant content in targeted T cells. In some embodiments, the present disclosure pertains to methods of modulating T cells ex-vivo by incubating the T cells with a carbon material. |
申请公布号 |
WO2015034930(A1) |
申请公布日期 |
2015.03.12 |
申请号 |
WO2014US53909 |
申请日期 |
2014.09.03 |
申请人 |
WILLIAM MARSH RICE UNIVERSITY;BAYLOR COLLEGE OF MEDICINE |
发明人 |
TOUR, JAMES, M.;BEETON, CHRISTINE;HUQ, REDWAN, U.;INOUE, TAEKO;PAUTLER, ROBIA, G.;SAMUEL, ERROL, L.G. |
分类号 |
A61P29/00;A61K33/40 |
主分类号 |
A61P29/00 |
代理机构 |
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