| 摘要 |
The application relates to a process for preparing a lypohilized formulation, comprising the steps of: (i) providing (1) a chitosan hydrogel, the chitosan hydrogel being obtainable by providing a chitosan having a degree of deacetylation between 30 and 75%, wherein the chitosan is randomly deacetylated, and a cross-linking agent, wherein the molar ratio of the cross-linking agent to chitosan is 0.2:1 or less based on the number of functional groups in the cross-linking agent and the number of deacetylated amino groups in the chitosan in an aqueous solution, and (2) a liquid dispersed in the hydrogel; cross-linking the composition and isolating the resultant chitosan hydrogel emulsion; and (ii) processing the chitosan hydrogel emulsion to give fragments; and (iii) lypophilizing the fragments of chitosan hydrogel emulsion. Formulations obtainable by the process, and their pharmaceutical uses are also disclosed. |
