THE COMPOSITION OF REYNOUTRIA ELLIPTICA EXTRACT INGREDIENTS FOR TREATMENT AND PREVENTION OF OSTEOPOROSIS

摘要

The present invention relates to a composition for treating and preventing osteoporosis, which contains a Reynoutria elliptica extract for suppressing differentiation of osteoclasts for accelerating bone resorption, and bone resorption. A Brassica juncea extract reduces trartrate-resistant acid phosphatase (TRAP), which is accelerated in the osteoclast forming process during differentiating macrophage (mouse macrophage RAW264.7) into osteoclasts, and reduces bone resorption. Carbonic anhydrase is an enzyme secreting hydrogen ions and acidifying the resorption lacuna site, and continuous bone resorption in the resorption lacuna site is possible due to V-ATPase, an enzyme sending carbonic anhydrase to the outside, which is suppressed by a Reynoutria elliptica extract. Accordingly, the present invention relates to a composition for treating and preventing osteoporosis capable of suppressing the expression of carbonic anhydrase II and V-ATPase, which are engaged in bone resorption, by a Reynoutria elliptica extract inhibiting the differentiation of osteoclasts.