发明名称 |
SITE-SPECIFIC LABELING METHODS AND MOLECULES PRODUCED THEREBY |
摘要 |
The present disclosure provides methods of site-specific labeling of antibodies, using proteins having 4′-phosphopantetheinyl transferase activity that catalyze post-translational modification of peptide sequences (“peptide tags”) incorporated into one or more specific sites of an antibody of interest. Enzymatic labeling enables quantitative and irreversible covalent modification of a specific serine residue within the peptide tags incorporated into the antibody, and thus creates desirable antibody conjugates. |
申请公布号 |
KR20150027072(A) |
申请公布日期 |
2015.03.11 |
申请号 |
KR20147033685 |
申请日期 |
2013.05.31 |
申请人 |
IRM LLC |
发明人 |
GEIERSTANGER BERNHARD HUBERT;GRUNEWALD JAN;BURSULAYA BADRY |
分类号 |
A61K47/48;C07K1/107;C07K1/13;C07K16/30 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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