METHOD OF SCREENING A SUBSTANCE CAPABLE OF INHIBITING INTERACTION BETWEEN PRP19 AND CLIC PROTEINS AND A COMPOSITION COMPRISING THE SCREENED SUBSTANCE

摘要

A method for searching materials inhibiting the interaction between PRP19 and CLIC protein is provided to inhibit the formation of adipose, prevent and treat the disease mediated by the interaction between PRP19 and CLIC protein. A method for searching a material which inhibits the interaction between PRP19 and CLIC protein comprises: a step of reacting PRP19 protein or it U-box domain and CLIC protein; a step of measuring the amount of probe; and a step of selecting candidate material which decreases the amount of probe. A cosmetic composition contains 0.0001-20 weight% Elaeocarpus sylvestrisvar.ellipticus (Thunb.)Hara extract as an active ingredient. A pharmaceutical composition for preventing and treating obesity contains 0.0001-100 weight% of Elaeocarpus sylvestrisvar.ellipticus (Thunb.)Hara extract.