DOSE-RESPONSE MEDICAL OUTCOME MODEL PREDICTOR SYSTEM AND METHOD

摘要

A computer-implemented method for predicting quantitatively whether an adjuvant or neoadjuvant chemotherapeutic is successful in treating an individual suffering from cancer, the method comprising the steps of assaying a cancerous biological sample and a normal biological sample from the individual to determine the concentration of two or more BCL-2 family members in each sample; inputting the concentration value for at least two BCL-2 family members of each sample into a non-linear protein-protein network computational model and adapted to calculate quantitative protein profiles over time from quantitative molecular interaction data and assess the mitochondrial outer membrane permeabilisation apoptosis pathway invoked by chemotherapeutically-induced stress; and processing said concentration values using said computational model to determine the interaction of pro-apoptotic and pro-survival BCL-2 family members invoked after chemotherapeutic-induced stress in the sample; and outputting a quantitative prediction value of the likelihood of treatment success using the adjuvant or neoadjuvant chemotherapeutic treatment.