发明名称 Method for forming nano-bubble
摘要 The present invention discloses a method for forming a nano-bubble. The forming method is different from the oil-water emulsion reaction in the prior art. The method comprises: taking an inorganic particle as a nucleus and performing a polymer coating process to coat at least one first polymer on the surface of the nucleus to form an organic/inorganic composite particle; then removing the nucleus of the organic/inorganic composite particle by way of the dissolution of a first solvent to form an impregnated nano-particle; performing a freeze-drying process to remove the first solvent to have the impregnated nano-particle form a hollow nano-particle; and finally dissolving the hollow nano-particle in a second solvent to form the nano-bubble.
申请公布号 US8974770(B2) 申请公布日期 2015.03.10
申请号 US200912423956 申请日期 2009.04.15
申请人 Chung Yuan Christian University 发明人 Chang Walter H.;Lin Cheng-An;Lee Chih-Hsien;Yeh Chih-Kuang
分类号 A61K49/18;A61K49/22;A61K47/30;B82Y5/00 主分类号 A61K49/18
代理机构 WPAT, PC 代理人 WPAT, PC ;King Justin
主权项 1. A method for forming a nano-bubble, the method comprising: taking an inorganic particle as a nucleus and performing a polymer coating process to coat (poly(isobutylene-alt-maleic anhydride)-graft-dodecylamine) on the nucleus to form an organic/inorganic composite particle, wherein the inorganic particle is one particle selected from the group consisting of the following: gold, silver, and iron; dripping aqua regia into a solution containing said organic/inorganic composite particle to dissolve said nucleus; using a 100 KDa filter tube to replace aqua regia with sodium borate buffer (SBB), and then replacing the SBB with deionized water to remove the dissolved nucleus of the organic/inorganic composite particle, and forming an impregnated nano-particle impregnated with the deionized water; performing a freeze-drying process on the impregnated nano-particle to form a hollow nano-particle; and placing the hollow nano-particle into the deionized water to form the nano-bubble in the deionized water; wherein the nano-bubble has a particle diameter of 30-100 nm.
地址 Tao-Yuan TW