Therapeutic agent delivery system, device and method for localized application of therapeutic substances to a biological conduit

摘要

The invention provides a system, device and method for localized application of therapeutic substances within a biological conduit. In various embodiments, a dissolvable bag or bolus of at least one therapeutic agent is introduced and pressed and/or sealed against the wall of conduit. In other embodiments, dissolvable barbs formed from at least one therapeutic agent are ejected from a catheter by fluid pressure, embedding in the wall of conduit.

主权项

1. A system for local delivery and application of a bolus of at least one therapeutic agent to the inner wall of a biological conduit following a procedure to open the biological conduit by treating an occlusion therein, comprising:
an expandable stent having an outer surface, the stent capable of delivery to the biological conduit and then expanding within the conduit; and a bag comprising a first dissolvable or biodegradable material and a second dissolvable or biodegradable material, the bag containing a dose of at least one therapeutic agent therein; wherein the bag is disposed on the outer surface of the expandable stent, the second dissolvable or biodegradable material is attached to, and wraps continuously radially around, the outer surface of the expandable stent, wherein the first dissolvable or biodegradable material is pressured and disposed against the inner wall of the biological conduit as a result of the pressuring of the expanding stent against the second dissolvable or biogradeable material, wherein the first dissolvable or biodegradable material dissolves or biodegrades before the second dissolvable or biodegradable material dissolves or biodegrades such that when the first dissolvable or biodegradable material dissolves or biodegrades, the dose of the at least one therapeutic agent is thereby exposed to the inner wall of the biological conduit, and wherein the pressure of the expanding stent against the second dissolvable or biodegradable material retains the dose of the at least one therapeutic agent in place to treat the trauma until the second dissolvable or biodegradable material dissolves or biodegrades.