Use of boswellic acids for the prophylaxis and/or treatment of damage to and/or inflammation of the islets of Langerhans

摘要

Disclosed are methods and compositions related to the use of boswellic acids (such as acetyl-11-keto-β-boswellic acid, 11-keto-β-boswellic acid, β-boswellic acid, acetyl-β-boswellic acid, 9,11-dehydro-β-boswellic acid, acetyl-9,11-dehydro-β-boswellic acid, α-boswellic acid, acetyl-α-boswellic acid, 11-dehydro-α-boswellic acid, acetyl-9,11-dehydro-α-boswellic acid, lupeolic acid, acetyl lupeolic acid, 12-ursene-2-diketone, incensole, incensole acetate, a derivative, in particular an ester thereof, a pharmaceutically acceptable salt thereof, a combination thereof, or a preparation containing one or more of these compounds) for the human medical or veterinary prophylaxis and/or treatment of: a) damage to and/or inflammation of the islets of Langerhans and/or b) damage to the B-cells of the islets of Langerhans.

主权项

1. A method of ameliorating insulitis without treating diabetes mellitus in a subject in need thereof, comprising:
providing the subject in need of treatment for insulitis; and administering to said subject a composition comprising a compound selected from the group consisting of: acetyl-11-keto-β-boswellic acid, 11-keto-β-boswellic acid, β-boswellic acid, acetyl-β-boswellic acid, 9, 11-dehydro-β-boswellic acid, acetyl-9, 11-dehydro -β-boswellic acid, α-boswellic acid, acetyl-α-boswellic acid, 11-dehydro-α-boswellic acid, acetyl-9,11-dehydro-α-boswellic acid, lupeolic acid, acetyl-lupeolic acid, 12-ursene-2-diketone, incensole, incensole acetate, derivatives thereof, esters thereof, pharmaceutically acceptable salts thereof, and combinations thereof, whereby damage to and/or inflammation of the islets of Langerhans and/or damage to the B-cells of the islets of Langerhans is treated, wherein a dose in the range from about 0.4 mg/kg to about 8.0 mg/kg of the composition is administered to the subject.