| 发明名称 |
Method for predicting a need for renal replacement therapy (RRT) |
| 摘要 |
A method for predicting a need for Renal Replacement Therapy (RRT) in a patient comprises: determining a concentration of pi glutathione S transferase-(πGST) in a first urine sample from the patient; and wherein a need for RRT is predicted when the πGST concentration is determined to be elevated in comparison to a patient without kidney injury. The method according to the invention can further comprise detecting for the presence of risk factors for RRT in a patient, the risk factors including elevated serum creatinine concentration, type I diabetes, type II diabetes, hypertension, dyslipidemia, hyperglycaemia, proteinuria and hypoalbuminemia. |
| 申请公布号 |
US8975031(B2) |
申请公布日期 |
2015.03.10 |
| 申请号 |
US201313866540 |
申请日期 |
2013.04.19 |
| 申请人 |
|
发明人 |
Kilty Cormac Gerard;Koyner Jay Lawrence;McGrath Claire Victoria;Murray Patrick Thomas;Schuster Kerstin |
| 分类号 |
G01N33/53;G01N33/68 |
主分类号 |
G01N33/53 |
| 代理机构 |
Birch, Stewart, Kolasch & Birch, LLP. |
代理人 |
Birch, Stewart, Kolasch & Birch, LLP. |
| 主权项 |
1. A method for treating acute kidney injury consisting of:
determining a concentration of pi glutathione S transferase-(πGST) in a urine sample from a patient; and performing Renal Replacement Therapy (RRT) when the πGST concentration is determined to be greater than 500% relative to a baseline in comparison to a patient without kidney injury, thereby indicating severe acute kidney injury and a requirement for RRT, wherein said patient has not undergone renal transplantation. |
| 地址 |
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