Protein skeletal module which increases the binding affinity and binding specificity of active polypeptides

摘要

The present invention relates to a novel protein skeletal module which increases the binding affinity or binding specificity of active polypeptides. More particularly, the present invention relates to a protein skeletal module comprising polypeptides consisting of the 1st to 19th amino acids of the amino acid sequence expressed in sequence number 1; polypeptides comprising active polypeptides; and polypeptides consisting of the 29th to 86th amino acids of the amino acid sequence expressed in sequence number 1. The present invention also relates to a method for preparing the protein skeletal module. The protein skeletal module of the present invention increases the binding affinity or binding specificity of active polypeptides embedded therein, and therefore is effective in diagnosing and treating diseases.

主权项

1. A scaffold protein comprising an active polypeptide, the scaffold protein comprising:
a) a polypeptide consisting of the 1st to the 19th amino acid residues of an amino acid sequence represented by SEQ ID NO: 1; b) a polypeptide including an active polypeptide; and c) a polypeptide consisting of the 29th to the 86th amino acid residues of the amino acid sequence represented by SEQ ID NO: 1, wherein the polypeptides are sequentially linked.