| 发明名称 | Process for preparing 2,2-difluoroethanol | ||
| 摘要 | Process for preparing 2,2-difluoroethanol, comprising the following steps: reacting 1-chloro-2,2-difluoroethane with an alkali metal salt of formic acid or acetic acid in a suitable solvent to give the corresponding 2,2-difluoroethyl formate or 2,2-difluoroethyl acetate, and transesterifying the 2,2-difluoroethyl formate or 2,2-difluoroethyl acetate from step (i) in the presence of an alcohol and optionally of a base. | ||
| 申请公布号 | US8975448(B2) | 申请公布日期 | 2015.03.10 |
| 申请号 | US201214232170 | 申请日期 | 2012.07.16 |
| 申请人 | Bayer Intellectual Property GmbH | 发明人 | Müller Thomas Norbert;Lui Norbert;Moczarski Stefan |
| 分类号 | C07C29/147;C07C67/11;C07C29/128;C07C67/10;C07C31/38 | 主分类号 | C07C29/147 |
| 代理机构 | Miles & Stockbridge PC | 代理人 | Miles & Stockbridge PC |
| 主权项 | 1. A process for preparing 2,2-difluoroethanol, comprising: (i): reacting 1-chloro-2,2-difluoroethane with an alkali metal salt of formic acid or acetic acid in a suitable solvent to give the corresponding 2,2-difluoroethyl formate or 2,2-difluoroethyl acetate, wherein, 1-chloro-2,2-difluoroethane is added gradually to a mixture, heated to a desired reaction temperature, of solvent and alkali metal salt of formic acid or acetic acid; (ii): transesterifying the 2,2-difluoroethyl formate or 2,2-difluoroethyl acetate from (i): in the presence of an alcohol and optionally of a base. | ||
| 地址 | Monheim am Rhein DE | ||