| 主权项 |
1. A dosage unit form comprising (a) glucagon, and (b) a delivery agent of the formulaand salts thereof, wherein:
Ar is 2-hydroxyphenyl or 2-hydroxynaphthyl; Ar is optionally substituted with one or more of —OH, halogen, C1-C4 alkyl, C2-C4 alkenyl, C1-C4 alkoxy or C1-C4 haloalkoxy; R7 is selected from C4-C20 alkyl, C4-C20 alkenyl, phenyl, naphthyl, (C1-C10 alkyl) phenyl, (C2-C10 alkenyl)phenyl, (C1-C10 alkyl) naphthyl, (C2-C10 alkenyl)naphthyl, phenyl(C1-C10 alkyl), phenyl(C2-C10 alkenyl), naphthyl(C1 -C10 alkyl), or naphthyl(C2-C10 alkenyl); R8 is selected from hydrogen, C1-C4 alkyl, C2-C4 alkenyl, C1-C4 alkoxy, and C1-C4 haloalkoxy; R7 is optionally substituted with C1-C4 alkyl, C2-C4 alkenyl, C1-C4 alkoxy, C1-C4 haloalkoxy, —OH, —SH, and —CO2R9, or any combination thereof; R9 is hydrogen, C1-C4 alkyl, or C2-C4 alkenyl; and R7 is optionally interrupted by oxygen, nitrogen, sulfur or any combination thereof, wherein the dosage unit form is suitable for intraoral administration. |
