Process to control CO concentrations in fermentations

摘要

A process for controlling concentration of CO in a bioreactor provides a direct and real time measurement of dissolved CO in a fermentation medium. The process for controlling concentrations of CO in a bioreactor includes contacting an aliquot of fermentation medium with at least one CO binding ligand and at least one microbial inactivator.

主权项

1. A process for controlling the concentration of carbon monoxide (CO), in an aqueous fermentation medium comprising CO, the process comprising:
a) combining part of the fermentation medium with at least one CO binding ligand and b) measuring the amount of CO bound to the CO binding ligand, wherein at least a portion of the CO is bound to the CO binding ligand.