Anti-bacterial vaccine compositions with a mutated yleA gene

摘要

Gram negative bacterial virulence genes are identified, thereby allowing the identification of novel anti-bacterial agents that target these virulence genes and their products, and the provision of novel gram negative bacterial mutants useful in vaccines.

主权项

1. An isolated, attenuated Pasteurella multocida bacterium comprising a mutation in a polynucleotide sequence that encodes the yleA polypeptide of SEQ ID NO: 81, wherein said mutation results in a mutated yleA polypeptide.