发明名称 |
Glycoconjugates of RNA Interference Agents |
摘要 |
The present invention relates to agents, compositions and methods for inhibiting the expression of a target gene, comprising an RNAi agent bearing at least one galactosyl moiety. These are useful for delivering the gene expression inhibiting activity to cells, particularly hepatocytes, and more particularly in therapeutic applications. |
申请公布号 |
US2015065558(A1) |
申请公布日期 |
2015.03.05 |
申请号 |
US201414500356 |
申请日期 |
2014.09.29 |
申请人 |
ALNYLAM PHARMACEUTICALS, INC. |
发明人 |
Forst Andrea;Hadwiger Philipp;Vornlocher Hans-Peter |
分类号 |
C12N15/113;A61K47/48;A61K31/713 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
CAMBRIDGE MA US |