A method of making a 2-halonicotinonitrile comprises reacting an alkylidene nitrile with a C1-compound in an organic solvent and a dehydrating agent. The dehydrating agent substantially retards dimerization of the alkylidene nitrile during the reaction. The enamine intermediate that forms from the reaction is cyclized using a halide donor to make the 2-halonicotinonitrile.
申请公布号
WO2015031718(A1)
申请公布日期
2015.03.05
申请号
WO2014US53344
申请日期
2014.08.29
申请人
MCQUADE, D., TYLER;GUPTON, B., FRANK;LONGSTREET, ASHLEY, R.;OPALKA, SUZANNE, M.
发明人
MCQUADE, D., TYLER;GUPTON, B., FRANK;LONGSTREET, ASHLEY, R.;OPALKA, SUZANNE, M.