DEVICE AND METHODS OF USING DEVICE FOR DETECTION OF HYPERAMMONEMIA
摘要
The present disclosure relates to a biosensor capable of measuring the total concentration of one or a plurality of ammonia or ammonium ions with the use of indophenol reagents in the presence of an ionomer. In some embodiments, the biosensor comprises a perflurinated membrane that comprises an ionomer in contact with an alkaline buffer in a vessel configured to receive a sample, such as whole blood. The disclosure also relates to a method of detecting or quantifying the ammonia or ammonium ion concentration in whole blood in a point of care biosensor without reliance on gas chromatography or any measurement that takes more than about twenty minutes.
申请公布号
WO2015031911(A1)
申请公布日期
2015.03.05
申请号
WO2014US53756
申请日期
2014.09.02
申请人
UNIVERSITY OF MARYLAND, COLLEGE PARK;CHILDREN'S NATIONAL MEDICAL CENTER
发明人
AYYUB, OMAR BILAL;BEHRENS, ADAM MICHAEL;KOFINAS, PETER;SUMMAR, MARSHALL LYNN;CABRERA-LUQUE, JUAN MANUEL;CUNNINGHAM, GARY