发明名称 |
ENGINEERED PRIMATE CYSTINE/CYSTEINE DEGRADING ENZYMES AS ANTINEOGENIC AGENTS |
摘要 |
Methods and compositions related to the engineering of a protein with L-cyst(e)ine degrading enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-γ-lyase comprising one or more amino acid substitutions and capable of degrading L-cyst(e)ine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with L-cyst(e)ine using the disclosed proteins or nucleic acids. |
申请公布号 |
US2015064160(A1) |
申请公布日期 |
2015.03.05 |
申请号 |
US201414472779 |
申请日期 |
2014.08.29 |
申请人 |
Board of Regents, The University of Texas System |
发明人 |
GEORGIOU George;STONE Everett |
分类号 |
A61K45/06;A61K38/51;C12N9/88 |
主分类号 |
A61K45/06 |
代理机构 |
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代理人 |
|
主权项 |
1. An isolated, modified primate cystathionine-γ-lyase (CGL) enzyme having at least one substitution relative to a native primate CGL amino acid sequence (see SEQ ID NOs: 1 and 7-10), said at least one substitution including a threonine at position 59 of the native primate CGL sequence. |
地址 |
Austin TX US |