| 摘要 |
<p>(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization II International Bureau (43) International Publication Date H(10) International Publication Number 8 March 2012 (08.03.2012) PCT W O 2012/030919 A2 (51) International Patent Classification: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, A61K31/19 (2006.01) A61K31/185 (2006.01) DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, A61K 31/192 (2006.01) A61P 21/00 (2006.01) HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, (21) International Application Number: KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, PCT/Urai0lA1i049905:ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, PCT/US2011/049905 NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, (22) International Filing Date: RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, 31 August 2011 (31.08.2011) TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (25) Filing Language: English (84) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of regional protection available): ARIPO (BW, GH, (30) Priority Data: GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, 61/378,996 1 September 2010 (01.09.20 10) US ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (71) Applicant (for all designated States except US): EE, ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, THOMAS JEFFERSON UNIVERSITY [US/US]; 1020 LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Walnut Street, Philadelphia, Pennsylvania 19107 (US). SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (72) Inventors; and GW, ML, MR, NE, SN, TD, TG). (75) Inventors/Applicants (for US only): IWAMOTO, Declarations under Rule 4.17: Masahiro [JP/US]; 613 Radnor Valley Drive, Villanova - as to applicant's entitlement to apply for and be granted Pennsylvania 19085 (US). PACIFICI, Maurizio a patent (Rule 4.17(ii)) [US/US]; 440 South Broad Street, Philadelphia, Pennsyl vania 19146 (US). - as to the applicant's entitlement to claim the priority of - the earlier application (Rule 4.1 7(iii)) (74) Agents: RESNICK, David, S. et al.; Nixon Peabody LLP, 100 Summer St., Boston, Massachusetts Published: 02110-2131 (US). - without international search report and to be republished (81) Designated States (unless otherwise indicated, for every upon receipt of that report (Rule 48.2(g)) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, (54) Title: COMPOSITION AND METHOD FOR MUSCLE REPAIR AND REGENERATION F G UNINJURED CONTROL FI.- E INJUREDCONTROL [36D1530 (57) Abstract: The invention provides methods for muscle repair or regeneration comprising administering therapeutically effec tive amounts of RAR agonists or stem cells that are pretreated with contact with a RAR agonist to a subject at a site of muscle f4 damage. Additionally, the invention provides compositions comprising RAR agonist treated stem cells and methods of use of said cells for muscle repair or regeneration. i one embodiment, the stem cells are mesenchymal stem cells. i one embodiment, the RAR agonist is an RART agonist. i one embodiment, administration of the RAR agonist is begun during a period of increased endogenous retinoid signaling in the subject resulting from incurrence of the damaged muscle tissue.</p> |
