发明名称 |
Methods for stabilizing production of acetyl-coenzyme a derived compounds |
摘要 |
<p>The present disclosure relates to the use of a switch for the production of heterologous non-catabolic compounds in microbial host cells. In one aspect, provided herein are genetically modified microorganisms that produce non-catabolic compounds more stably when serially cultured under aerobic conditions followed by microaerobic conditions, and methods of producing non-catabolic compounds by culturing the genetically modified microbes under such culture conditions. In another aspect, provided herein are genetically modified microorganisms that produce non-catabolic compounds more stably when serially cultured in the presence of maltose followed by the reduction or absence of maltose, and methods of producing non-catabolic compounds by culturing the genetically modified microbes under such culture conditions.</p> |
申请公布号 |
AU2013299608(A1) |
申请公布日期 |
2015.03.05 |
申请号 |
AU20130299608 |
申请日期 |
2013.08.07 |
申请人 |
AMYRIS, INC.;TOTAL MARKETING SERVICES |
发明人 |
JIANG, HANXIAO;MEADOWS, ADAM |
分类号 |
C12N15/52;C12N1/20 |
主分类号 |
C12N15/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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