| 发明名称 |
DEVELOPMENT OF MUTATIONS USEFUL FOR ATTENUATING DENGUE VIRUSES AND CHIMERIC DENGUE VIRUSES |
| 摘要 |
A menu of mutations was developed that is useful in fine-tuning the attenuation and growth characteristics of dengue virus vaccines. |
| 申请公布号 |
US2015064214(A1) |
申请公布日期 |
2015.03.05 |
| 申请号 |
US201314096424 |
申请日期 |
2013.12.04 |
| 申请人 |
The USA, as represented by the Secretary, Department of Health & Human Services |
发明人 |
Whitehead Stephen S.;Murphy Brian R.;Hanley Kathryn A.;Blaney Joseph E.;Lai Ching-Juh |
| 分类号 |
A61K39/12;C12N7/00;C12Q1/70;A61K39/295 |
主分类号 |
A61K39/12 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A flavivirus having a phenotype in which the viral genome is modified by the introduction of a mutation, singly or in combination, taken from the group consisting of the mutations of any of Table 1-37, preferably Table 37. |
| 地址 |
Rockville MD US |
