METHODS OF TREATING CANCER HAVING AN ACTIVE WNT/BETA-CATENIN PATHWAY

摘要

The present invention provides methods of treating a subject having a Wnt/beta-catenin active cancer by administering to said subject a compound that inhibits the expression or activity of YES1, BIRC5 or BCL2L1, a compound that inhibits YAP1-beta-catenin complex formation, a compound that inhibits YAP1-beta-catenin complex binding to DNA, a compound that inhibits YAP1-beta-catenin-TBX5 complex formation, or any combination thereof. The compound can be, for example, a nucleic acid, a peptide, an antibody or a small molecule. Methods of screening for therapeutic targets for treating cancer are included.

主权项

1. A method of treating a subject having a Wnt/β-catenin active cancer comprising administering to said subject
(a) a compound that inhibits the expression of activity of YES1, BIRC5 or BCL2L1; (b) a compound that inhibits YAP1 beta-catenin complex formation; (c) a compound that inhibits YAP1-beta-catenin-TBX5 complex formation; (d) a compound that inhibits YAP1-beta-catenin-TBX5 complex binding to DNA; or (e) any combination thereof.