| 发明名称 |
LIPID-COATED NUCLEIC ACID NANOSTRUCTURES OF DEFINED SHAPE |
| 摘要 |
The invention provides nanoparticles containing a nucleic acid nanostructure, of defined shape and size, linked to a hydrophobic moiety and coated by lipids, compositions comprising the nanoparticles, and methods of producing and methods of using the nanoparticles. |
| 申请公布号 |
US2015064233(A1) |
申请公布日期 |
2015.03.05 |
| 申请号 |
US201314387645 |
申请日期 |
2013.03.13 |
| 申请人 |
President and Felllows of Harvard College |
发明人 |
Shih William M.;Perrault Steven |
| 分类号 |
A61K9/127;A61K47/48 |
主分类号 |
A61K9/127 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A nanoparticle having a nucleic acid nanostructure core and a lipid coating, wherein the nucleic acid nanostructure is attached to a hydrophobic moiety through
(a) a single-stranded oligonucleotide conjugate comprising the hydrophobic moiety, or (b) a binding pair, one member of which is attached to the nanostructure and one member of which is attached to the hydrophobic moiety, wherein the hydrophobic moiety is in contact with the lipid coating. |
| 地址 |
Cambridge MA US |
