HIGH THROUGHPUT LABEL FREE NANOPARTICLE DETECTION AND SIZE ASSAY

摘要

The present invention reports a novel microfluidic analyzer for the high-throughput, label-free measurement of particles suspended in a fluid. The present invention employs the resistive pulse technique (RPT) which affords very high electrical bandwidth for the device, which surpasses that of currently available systems and devices. Further, devices in accordance with the present invention are fabricated with very simple microfabrication technologies, making the present invention more cost efficient and easier to manufacture than currently available devices.

主权项

1. An apparatus for detecting particles in a fluid, comprising:
a first electrode; a sensing electrode; a fluid resistor between the first electrode and the sensing electrode; a second electrode; and a constriction between the sensing electrode and the second electrode, wherein a bias voltage is applied between the first electrode and the second electrode to create a current through the fluid, such that one or more properties for particles in the fluid are sensed by a change in voltage sensed at the sensing electrode.