| 主权项 |
1. A computer system adapted to determine sensitivity to breast cancer neoadjuvant chemotherapy comprising:
a processor, and a memory, under control of said processor, including software instructions adapted to enable the computer system to perform operations comprising: (1) acquiring an information of an expression level of each gene of (A1) to (A19) below in a measurement sample comprising RNA from a specimen collected from a subject, (2) analyzing the expression level of the each gene acquired in the step (1), and (3) determining sensitivity to breast cancer neoadjuvant chemotherapy on the basis of an analysis result obtained in the step (2): (A1) human caspase recruitment domain family, member 9 (CARD9) gene, (A2) human indoleamine-2,3-dioxygenase 1 (IDO1) gene, (A3) human chemokine (C-X-C motif) ligand 9 (CXCL9) gene, (A4) human purine nucleoside phosphorylase (PNP) gene, (A5) human chemokine (C-X-C motif) ligand 11 (CXCL11) gene, (A6) human CCAAT/enhancer binding protein (CEBPB) gene, (A7) human CD83 gene, (A8) human interleukin 6 signal transducer (IL6ST) gene, (A9) human chemokine (C-X3-C) receptor 1 (CX3CR1) gene, (A10) human CD1D gene, (A11) human cathepsin C (CTSC) gene, (A12) human chemokine (C-X-C motif) ligand 10 (CXCL10) gene, (A13) human immunoglobulin heavy chain genetic locus G1 isotype (IGHG1) gene, (A14) human zinc finger E-box-binding homeobox 1 (ZEB1) gene, (A15) human vascular endothelial growth factor A (VEGFA) gene, (A16) human semaphorin-3C precursor (SEMA3C) gene, (A17) human complement receptor (CR2) gene, (A18) human HFE gene, and (A19) human EDA gene. |
