S100A8/A9 as a Diagnostic Marker and a Therapeutic Target

摘要

Determinations of the level of expression of S100A8/A9 protein serve as a prognostic indicator of the therapeutic response to a given type of chemotherapy treatment and as a monitoring indicator of the effectiveness of an on-going chemotherapy treatment for the treatment of breast cancer in human patients. Kits can be used for performing these determinations.

主权项

1. A method for treating lung or breast cancer in a patent suffering from lung or breast cancer comprising the steps of:
(a) evaluating a patient sample to determine the amount of S100A8/A9 protein present; (b) assessing responsiveness to chemotherapy treatments by comparing the determined amount of S100A8/A9 protein to a relevant standard value; and (c) administering a chemotherapy agent to the patient, wherein the chemotherapy agent is selected from among standard of care chemotherapy agents if the determined amount of S100A8/A9 is less than the relevant standard value, and selected from chemotherapy agents that are directed to one or components of a TNF-α-CXCL 1/2-S100A8/A9 survival axis if the determined value is greater than the relevant standard value.