| 主权项 |
1. A method of enhancing the immune response against an acute viral influenza infection of a first subtype, the method comprising:
(i) co-administration of an inactive influenza vaccine of a second subtype, distinct from the first subtype and a mismatched dsRNA, or (ii) administration of a composition comprising an inactive influenza vaccine of a second subtype, distinct from the first subtype and a mismatched dsRNA, wherein the mismatched dsRNA is rIn·r(C12,U)n, in which n is an integer, rI is polyriboinosinic acid and r(C12,U) is a polyribocytidylic acid sequence containing unpaired uracils, wherein the mismatched dsRNA acts as an adjuvant or immuno-stimulant, and wherein the method results in an enhanced immune response against the acute viral influenza infection of a first subtype compared to the administration of the inactive influenza vaccine of a second subtype without the mismatched dsRNA. |
