发明名称 |
MODULATING GENE EXPRESSION WITH agRNA AND GAPMERS TARGETING ANTISENSE TRANSCRIPTS |
摘要 |
Gene expression is selectively modulated in the genome of a mammalian cell determined to be in need thereof by determining the presence of an encoded antisense transcript overlapping a promoter of the target gene; contacting the transcript with an agRNA or gapmer complementary to a portion of the transcript upstream relative to the transcription start site of the gene; and detecting a resultant modulation of expression of the target gene. |
申请公布号 |
US2015064709(A1) |
申请公布日期 |
2015.03.05 |
申请号 |
US201414482950 |
申请日期 |
2014.09.10 |
申请人 |
Board of Regents, The University of Texas System |
发明人 |
SCHWARTZ Jacob C.;YOUNGER Scott T.;JANOWSKI Bethany A.;COREY David R. |
分类号 |
C12N15/63 |
主分类号 |
C12N15/63 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Austin TX US |