DUAL MODE SENSOR

摘要

A novel dual mode sensor may combine mass-sensing measurements of dynamic-mode cantilevers with electrochemical impedance spectroscopy employed for transduction in sensitive electrochemical biosensors. The integrated design of the sensor may provide simultaneous and continuous measurement of resonant frequency shift and charge transfer resistance of a target analyte bound to a surface of the sensor. Binding of a target analyte to the surface of the sensor may cause charge transfer resistance to increase and the resonant frequency of the sensor to decrease. These simultaneous dynamic modes of the sensor may be utilized to measure an amount of mass of the target analyte accumulated on the surface of the sensor and to reduce and/or eliminate false negative measurement results.

主权项

1. A method comprising:
performing a mass-sensing measurements via a sensor; performing a impedance measurements via the sensor; and determining, based on the mass-sensing measurements and the impedance measurements, whether an analyte has accumulated on the sensor.