发明名称 |
SYSTEMS, COMPOSITIONS, AND METHODS FOR TRANSPLANTATION AND TREATING CONDITIONS |
摘要 |
Systems and methods for purification and concentration of autologous alpha-2 macroglobulin (A2M) from whole blood and or recombinant A2M are provided. Also provided are methods of treating wounds with A2M. Methods for utilizing A2M in combination with other treatments (e.g., platelets and other growth factors) are provided in addition to combinations with exogenous drugs or carriers. Also provided is a method of producing recombinant A2M wild type or variants thereof where the bait region was modified to enhance the inhibition characteristics of A2M and/or to prolong the half-life of the protein for treating wounds. |
申请公布号 |
CA2922806(A1) |
申请公布日期 |
2015.03.05 |
申请号 |
CA20142922806 |
申请日期 |
2014.08.28 |
申请人 |
CYTONICS CORPORATION |
发明人 |
HANNA, LEWIS;LAUGHLIN, JOHN DAVID;BROWNING, SHAWN ROBERT |
分类号 |
A61K38/17;A61K35/16;A61K35/19;A61K39/395;A61K45/00;A61K47/48;A61L15/44;A61P17/02;B01L3/00;C07K14/47 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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