METHOD FOR SCREENING THERAPEUTIC AND/OR PROPHYLACTIC AGENTS FOR ALZHEIMER'S DISEASE

摘要

The present invention provides a method for screening a therapeutic and/or prophylactic agent for Alzheimer's disease using at least one index selected from the group consisting of the levels of Aβ oligomers, BiP, cleaved caspase 4, PRDX4 and ROS in nerve cells or the like whose differentiation has been induced from iPS cells derived from somatic cells of a patient with Alzheimer's disease.

主权项

1. A method for screening a therapeutic agent and/or prophylactic agent for Alzheimer's disease, said method comprising the steps of:
(a) bringing a candidate substance into contact with a nerve cell(s) or astrocyte(s) derived from an induced pluripotent stem (iPS) cell(s) prepared from a somatic cell(s) of a patient with Alzheimer's disease, or derived from an iPS cell(s) in which APP having deletion mutation of glutamic acid at position 693 has been introduced; (b) measuring the amount of Aβ oligomers in said nerve cell(s) or astrocyte(s); and (c) selecting said candidate substance as a therapeutic and/or prophylactic agent for Alzheimer's disease if the amount of Aβ oligomers is decreased as compared to a case where said candidate substance is not brought into contact.