发明名称 |
METHODS FOR TREATING CONDITIONS ASSOCIATED WITH MASP-2 DEPENDENT COMPLEMENT ACTIVATION |
摘要 |
In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C1q-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier. |
申请公布号 |
US2015064176(A1) |
申请公布日期 |
2015.03.05 |
申请号 |
US201414459656 |
申请日期 |
2014.08.14 |
申请人 |
Omeros Corporation ;University of Leicester |
发明人 |
Schwaeble Hans-Wilhelm;Tedford Clark E.;Parent James B.;Dudler Thomas;Demopulos Gregory A. |
分类号 |
C07K16/40;A61K39/395;A01N1/02;A61K45/06 |
主分类号 |
C07K16/40 |
代理机构 |
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代理人 |
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主权项 |
1. A method of inhibiting adverse effects of transplantation in a subject that has undergone, is undergoing, or will undergo an organ or tissue transplant procedure comprising administering to the subject, or pretreating the organ or tissue to be transplanted with, a composition comprising a monoclonal MASP-2 inhibitory antibody, or antigen-binding fragment thereof, that specifically binds to a portion of SEQ ID NO:6 and inhibits MASP 2 dependent complement activation. |
地址 |
Seattle WA US |