GENETICALLY MODIFIED NON-HUMAN MAMMALS AND CELLS

摘要

Genetically modified mammals are described which lack the mannan binding lectin associated serine protease MASP-2, together with methods and constructs for their production. Such mammals are useful as models for disorders of the complement system, and in the identification of treatments for such disorders. Also described are mammals which lack the associated protein MAp19; such mammals may also lack MASP-2.

主权项

1. A method for production of an antibody directed against a human MASP-2 and/or human MAp19 protein produced by an exogenous human gene in a genetically modified rodent, wherein the gene encoding endogenous MASP-2 polypeptide and/or the gene encoding endogenous MAp19 polypeptide is/are absent or partially absent or disrupted.