CORE-SATELLITE NANOCOMPOSITES FOR MRI AND PHOTOTHERMAL THERAPY

摘要

The present invention provides methods, compositions, systems, and kits comprising core-satellite nanocomposites useful for photothermal and/or MRI applications (e.g., tumor treatment and/or imaging). In certain embodiments, the core-satellite nanocomposites comprise: i) a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core, and ii) at least one satellite component attached to, or absorbed to, the biocompatible coating. In some embodiments, the nanoparticle core and satellite component are composed of near-infrared photothermal agent material and/or MRI contrast agent material. In further embodiments, the satellite component is additionally or alternatively composed of near-infrared optical dye material.

主权项

1. A method of treating and/or imaging at least one tumor in a subject comprising:
a) administering to a subject a composition comprising core-satellite nanocomposites, wherein said subject comprises at least one tumor, wherein said core-satellite nanocomposites individually comprise:
i) a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core, wherein said nanoparticle core comprises a first type of material selected from: near-infrared photothermal agent material and MRI contrast agent material, andii) at least one satellite component attached to, or absorbed to, said biocompatible coating, wherein said at least one satellite component comprises a second type of material selected from: said near-infrared photothermal agent material, said MRI contrast agent material, and near-infrared optical dye material, and wherein said treating is under conditions such that at least a portion of said core-satellite nanocomposites infiltrate said at least one tumor; and b) subjecting said subject to photothermal therapy and/or imaging, wherein said photothermal therapy: A) comprises the use of a treatment device that emits electromagnetic radiation, and B) causes said at least one tumor to be reduced in size or become undetectable; and wherein said imaging: A) comprises the use of an imaging device configured for MRI/NMR detection and/or optical detection, and B) causes said at least one tumor to be visualized ex-vivo.