| 主权项 |
1. A compound of Formula (0): or a stereoisomer or salt thereof, wherein:
ring A is a monocycle or a fused bicycle;Q is N or C, wherein when Q is N, then the bond between A1 and Q is not a double bond and the bond between Q and A4 is not a double bond;A1 is NR1, S or CR1;A2 is NR2, S or CR2;A3 is N or C;A4 is N; andone, two or three of A1-A4 are N, wherein:
R1 is selected from the group consisting of H, halogen, NRaRb, C1-C3 alkyl, C3-C7 cycloalkyl, C1-C3 alkoxy and 3-11 membered heterocyclyl, wherein R1 is optionally substituted by F, OH, CN, SH, CH3 or CF3;R2 is selected from the group consisting of H, NRaRb, C1-C6 alkyl, C3-C7 cycloalkyl, C1-C6 alkoxy, phenyl and 3-11 membered heterocyclyl, wherein R2 is optionally substituted by Rc; orR1 and R2 taken together form a cyclic group selected from the group consisting of C3-C7 cycloalkyl, phenyl and 3-11 membered heterocyclyl, wherein the cyclic group is optionally substituted by Rd;R4 is selected from the group consisting of H, C1-C6 alkyl, CH2F and CH2OH;R5 is 3-11 membered heterocyclyl optionally substituted by Re or C(═O)N(C1-C6 alkyl)2; orR4 and R5 together form a C3-C11 cycloalkyl optionally substituted by Re or a 3-11 membered heterocyclyl optionally substituted by Re;one of A5-A8 is N and the remaining are CR6 or all are CR6;R6, independently at each occurrence, is selected from the group consisting of H, F, Cl, NH2, NHCH3, N(CH3)2, OH, OCH3, OCHF2, OCH2F, OCF3, SH, SCH3, SCHF2, SCH2F, CN, CH3, CHF2, CH2F, CH2OH, CF3, NO2 and N3;Ra is selected from the group consisting of H and C1-C6 alkyl optionally substituted by C1-C3 alkoxy, F, OH, CN, SH, CH3 or CF3;Rb is selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy, C3-C6 cycloalkyl, C(O)Rg, phenyl and 3-11 membered heterocyclyl wherein Rb may be optionally substituted by C1-C3 alkoxy, F, OH, CN, SH, CH3 or CF3;Rc and Rd are each independently selected from the group consisting of halogen, —(X1)0-1—CN, —(X1)0-1—NO2, —(X1)0-1—SF5, —(X1)0-1—OH, —(X1)0-1—NH2, —(X1)0-1—N(H)(R1a), —(X1)0-1—N(R1b)(R1a), —(X1)0-1—CF3, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 heteroalkyl, C1-C6 alkoxy, C1-C6 alkylthio, oxo, —(X1)0-1—C1-C6 alkyl, —(X1)0-1—C3-C10 cycloalkyl, —O—C3-C10 cycloalkyl, —(X1)0-1-3-11 membered heterocyclyl, —(X1)0-1—C6-C10 aryl, —C(═O)(X1)1—C3-C10 cycloalkyl, —C(═O)(X1)1-3-11 membered heterocyclyl, —(X1)0-1—C(═Y1)N(H)(R1a), —(X1)0-1—C(═Y1)NH2, —(X1)0-1—C(═Y1)N(R1a)(R1b), —(X1)0-1—C(═Y1)OR1a, —(X1)0-1—C(═Y1)OH, —(X1)0-1—N(H)C(═Y1)(R1a), —(X1)0-1—N(R1b)C(═Y1)(R1a), —(X1)0-1—N(R1b)C(═Y1)(H), (X1)0-1—N(H)C(═Y1)OR1a, —(X1)0-1—N(R1b)C(═Y1)OR1a, —(X1)0-1—S(O)1-2R1a, —(X1)0-1—N(H)S(O)1-2R1a, —(X1)0-1—N(R1b)S(O)1-2R1a, —(X1)0-1—S(O)0-1N(H)(R1a), —(X1)0-1—S(O)0-1N(R1b)(R1a), —(X1)0-1—S(O)0-1NH2, —(X1)0-1—S(═O)(═NR1b)R1a, —(X1)0-1—C(═Y1)R1a, —(X1)0-1—C(═Y1)H, —(X1)0-1—C(═NOH)R1a, —(X1)0-1—C(═NOR1b)R1a, —(X1)0-1—NHC(═Y1)N(H)(R1a), —(X1)0-1—NHC(═Y1)NH2, —(X1)0-1—NHC(═Y1)N(R1b)(R1a), —(X1)0-1—N(R1a)C(═Y1)N(H)(R1a), —(X1)0-1—N(R1a)C(═Y1)N(R1a)(R1b), —(X1)0-1—N(R1a)C(═Y1)NH2, —(X1)0-1—OC(═Y1)R1a, —(X1)0-1—OC(═Y1)H, —(X1)0-1—OC(═Y1)OR1a, —(X1)0-1—OP(═Y1)(OR1a)(OR1b), —(X1)—SC(═Y1)OR1a and —(X1)—SC(═Y1)N(R1a)(R1b) wherein X1 is selected from the group consisting of C1-C6 alkylene, C1-C6 heteroalkylene, C2-C6 alkenylene, C2-C6 alkynylene, C1-C6 alkyleneoxy, C3-C7 cycloalkylene, 3-11 membered heterocyclylene and phenylene; R1a and R1b are each independently selected from the group consisting of C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 heteroalkyl, C3-C7 cycloalkyl, (C3-C7 cycloalkylene)C1-C6 alkyl, 3-11 membered heterocyclyl, (3-11 membered heterocyclylene)C1-C6 alkyl, C6 aryl, and (C6-C10 arylene)C1-C6 alkyl, or R1a and R1b when attached to the same nitrogen atom are optionally combined to form a 3-11 membered heterocyclyl comprising 0-3 additional heteroatoms selected from N, O and S; Y1 is O, NR1c or S wherein R1c is H or C1-C6 alkyl; wherein any portion of an Rc or Rd substituent, including R1a, R1b and R1c, at each occurrence is each independently further substituted by from 0 to 4 Rf substituents selected from the group consisting of halogen, CN, NO2, SF5, OH, NH2, —N(C1-C6 alkyl), —NH(C1-C6 alkyl), oxo, C1-C6 alkyl, —(C2-C6 alkynylene)-(3-11 membered heterocyclyl, wherein the heterocyclyl is optionally substituted by Re), C1-C6 hydroxyalkyl, C1-C6 heteroalkyl, C1-C6 alkoxy, C1-C6 alkylthio, C3-C7 cycloalkyl, 3-11 membered heterocyclyl, —C(═O)N(H)(C1-C6 alkyl), —C(═O)N(C1-C6 alkyl)2, —C(═O)NH2, —C(═O)OC1-C6 alkyl, —C(═O)OH, —N(H)C(═O)(C1-C6 alkyl), —N(C1-C6 alkyl)C(═O)(C1-C6 alkyl), —N(H)C(═O)OC1-C6 alkyl, —N(C1-C6 alkyl)C(═O)OC1-C6 (halo)alkyl, —S(O)1-2C1-C6 alkyl, —N(H)S(O)1-2C1-C6 alkyl, —N(C1-C6 alkyl)S(O)1-2C1-C6 alkyl, —S(O)0-1N(H)(C1-C6 alkyl), —S(O)0-1N(C1-C6 alkyl)2, —S(O)0-1NH2, —C(═O)C1-C6 alkyl, —C(═O)C3-C7 cycloalkyl, —C(═NOH)C1-C6 alkyl, —C(═NOC1-C6 alkyl)C1-C6 alkyl, —NHC(═O)N(H)(C1-C6 alkyl), —NHC(═O)N(C1-C6 alkyl)2, —NHC(═O)NH2, —N(C1-C6 alkyl)C(═O)N(H)(C1-C6 alkyl), —N(C1-C6 alkyl)C(═O)NH2, —OC(═O)C1-C6 alkyl, —OC(═O)OC1-C6 alkyl, —OP(═O)(OC1-C6 alkyl)2, —SC(═O)OC1-C6 alkyl and —SC(═O)N(C1-C6 alkyl)2, wherein any alkyl portion of Rf is optionally substituted with halogen;Re is selected from the group consisting of halogen, OH, C1-C6 alkyl and oxo; andRg is selected from the group consisting of C1-C6 alkyl and C3-C6 cycloalkyl. |
