SEROLOGIC CORRELATES OF PROTECTION AGAINST BACILLUS ANTHRACIS INFECTION
摘要
<p>Regions of B. anthracis protective antigen are provided representing sequences recognized by antibodies in subjects that have vaccine induced lethal toxin neutralizing anti-PA IgG responses. The recognition of these PA regions enhances the utility of anti-PA IgG reactivity as an immune correlate of protection against anthrax in a subject and increases predictive probability of survival. Also provided are vaccines that include at least one of these PA regions that when administered to a subject improve the predictive value of vaccine induced anti-PA IgG and TNA responses as immune correlates of protection against inhalation anthrax.</p>
申请公布号
WO2015031471(A1)
申请公布日期
2015.03.05
申请号
WO2014US52895
申请日期
2014.08.27
申请人
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES
发明人
SEMENOVA, VERA, A.;QUINN, CONRAD, P.;POHL, JAN;SVOBODA, PAVEL;DALTON, SHANNON;SCHIFFER, JARAD, M.