FULLY HUMAN ANTIBODIES AGAINST HUMAN RANKL

摘要

Therapeutic antibodies are described that can be used for treating or prevention of diseases associated with modulation of activity of human RANKL. In certain aspects, the disclosed invention is based upon discovering antibodies that are capable of binding to human RANKL. The disclosed antibodies are capable of blocking the interactions between RANKL and its receptor RANK. The disclosed antibodies could be administered to humans without additional modifications such as a "humanization" process. The antibodies could also be used as diagnostics and for research purposes. The described monoclonal antibodies are applicable for RANKL /RANK signaling cascade targeting in drug development for cancer and immunological disorders.